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Metformin useful in treating MS?

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My sister-in-law has suffered with MS since she was 20 years old. She is now 65 and confined to an electric wheelchair. She is being treated by one of the country’s leading experts on MS treatments. She has tried a number of experimental treatments, but has yet to be advised about Metformin.


Edited by don1942

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dowling gram

I was just reading about trials of metforman in treating solid cancer tumors and that's not the only disease they are trials using metforman. They are sometimes using it in connection with other drugs and sometimes alone.

Here'a what I read about cancer and Metforman



Abstract: Metformin is a widely used drug in today’s prescriptions by physicians due to its specific effects in treating and curing type II diabetes. Diabetes is a common disease that may occur throughout human life, and can increase the likelihood of the occurrence of various types of cancer, such as colon, rectum, pancreas and liver cancers, compared to non-diabetic patients. Metformin inhibits mTOR activity by activating ATM (ataxia telangiectasia mutated) and LKB1 (liver kinase B1) and then adenosine monophosphate-activated kinase(AMPK), and thus prevents protein synthesis and cell growth. Metformin can activate p53 by activatingAMPK and thereby ultimately stop the cell cycle. Given the potential of metformin in the treatment of cancer, it can be used in radiotherapy, chemotherapy and to improve the response to treatment inandrogen derivatives (ADT), and also, according to available evidence, metformin can also be used to prevent various types of cancers. Generally, metformin can: 1) reduce the incidence of cancers, 2) reduce the mortality from cancers, 3) increase the response to treatment in cancer cells when using radiotherapy and chemotherapy, 4) optimize tumor movement and reduce the malignancy, 5) reduce the likelihood of relapse, and 6) reduce the damaging effects of ADT. Therefore, this drug can be used as a complementary therapeutic agent for cancer treatment and prevention. In this review, we have summarized the data from various experimental and clinical studies and highlight the possible potential effects of metformin on cancer therapeutic responses.




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